Issue 36, 2015
From the journal:

Chemical Communications

Mechanism of DNA assembly as revealed by energy barriers†

Lin Niu,a   Xuyan Yang,a   Jihan Zhou,a   Chengde Mao,*b   Haojun Liangc  and  Dehai Liang*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences and the Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China
E-mail: dliang@pku.edu.cn

b Department of Chemistry, Purdue University, West Lafayette, Indiana, USA
E-mail: Mao@purdue.edu

c Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, P. R. China

Abstract

The mechanism of DNA assembly is revealed by analyzing the energy barriers during nucleation and growth. The assembly is controlled by two competing parameters: the conformation adjustment rate of DNA strands and the spreading rate of new strands on the nuclei surface, both of which are temperature dependent and can be tuned by sequence design.

Graphical abstract: Mechanism of DNA assembly as revealed by energy barriers

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Article information

DOI
https://doi.org/10.1039/C5CC00783F
Article type
Communication
Submitted
27 Jan 2015
Accepted
30 Mar 2015
First published
30 Mar 2015

Chem. Commun., 2015,51, 7717-7720

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Mechanism of DNA assembly as revealed by energy barriers

L. Niu, X. Yang, J. Zhou, C. Mao, H. Liang and D. Liang, Chem. Commun., 2015, 51, 7717 DOI: 10.1039/C5CC00783F

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