Issue 14, 2015

Non-hazardous Baeyer–Villiger oxidation of levulinic acid derivatives: alternative renewable access to 3-hydroxypropionates

Abstract

Baeyer–Villiger monooxygenases catalyze the energetically challenging oxidation of levulinates (4-oxopentanoates) to 3-hydroxypropionic acid (3-HPA) derivates under ambient conditions, replacing propellant-grade H2O2 with aerial oxygen as the oxidant. This reaction enables a new pathway to a platform for chemical 3-HPA, an important intermediate in the non-petrol based production of a variety of bulk chemicals (acrylates, malonates, 1,3-propanediol).

Graphical abstract: Non-hazardous Baeyer–Villiger oxidation of levulinic acid derivatives: alternative renewable access to 3-hydroxypropionates

Supplementary files

Article information

Article type
Communication
Submitted
07 Nov 2014
Accepted
05 Jan 2015
First published
13 Jan 2015

Chem. Commun., 2015,51, 2874-2877

Non-hazardous Baeyer–Villiger oxidation of levulinic acid derivatives: alternative renewable access to 3-hydroxypropionates

M. J. Fink and M. D. Mihovilovic, Chem. Commun., 2015, 51, 2874 DOI: 10.1039/C4CC08734H

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