Issue 1, 2015

Palladium catalyzed Csp2–H activation for direct aryl hydroxylation: the unprecedented role of 1,4-dioxane as a source of hydroxyl radicals

Abstract

A novel strategy for direct aryl hydroxylation via Pd-catalysed Csp2–H activation through an unprecedented hydroxyl radical transfer from 1,4-dioxane, used as a solvent, is reported with bio relevant and sterically hindered heterocycles and various acyclic functionalities as versatile directing groups.

Graphical abstract: Palladium catalyzed Csp2–H activation for direct aryl hydroxylation: the unprecedented role of 1,4-dioxane as a source of hydroxyl radicals

Supplementary files

Article information

Article type
Communication
Submitted
31 Aug 2014
Accepted
03 Nov 2014
First published
04 Nov 2014

Chem. Commun., 2015,51, 191-194

Author version available

Palladium catalyzed Csp2–H activation for direct aryl hydroxylation: the unprecedented role of 1,4-dioxane as a source of hydroxyl radicals

K. Seth, M. Nautiyal, P. Purohit, N. Parikh and A. K. Chakraborti, Chem. Commun., 2015, 51, 191 DOI: 10.1039/C4CC06864E

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