Incorporation of O6-methylguanine restricts the conformational conversion of the human telomere G-quadruplex under molecular crowding conditions

Abstract

Here we systematically studied the incorporation of O⁶-methylguanine (6mG) into different positions of the human telomere G-quadruplex. In contrast to the natural G-quadruplex, the 6mG incorporated G-quadruplexes impeded the conformational conversion of the G-quadruplex from a hybrid to a parallel structure under molecular crowding conditions in a K⁺ containing buffer.