Issue 8, 2016

Silver-catalyzed oxidative decarboxylation of difluoroacetates: efficient access to C–CF2 bond formation

Abstract

A mild, versatile and efficient method for the silver(I)-catalyzed oxidative decarboxylative gem-difluoromethylenation has been developed. The radical cascade reaction comprises the addition of an oxidatively generated difluoromethylene radical to the isonitrile functionality and subsequent homolytic aromatic substitution. It provides a novel and efficient access to the C–CF2 bond formation.

Graphical abstract: Silver-catalyzed oxidative decarboxylation of difluoroacetates: efficient access to C–CF2 bond formation

Supplementary files

Article information

Article type
Communication
Submitted
06 Nov 2015
Accepted
27 Nov 2015
First published
30 Nov 2015

Chem. Commun., 2016,52, 1598-1601

Silver-catalyzed oxidative decarboxylation of difluoroacetates: efficient access to C–CF2 bond formation

W. Wan, G. Ma, J. Li, Y. Chen, Q. Hu, M. Li, H. Jiang, H. Deng and J. Hao, Chem. Commun., 2016, 52, 1598 DOI: 10.1039/C5CC09179A

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