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Issue 93, 2015
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Combinatorial therapy for triple negative breast cancer using hyperstar polymer-based nanoparticles

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Abstract

We report the ability of a novel combinatorial therapy obtained from nanoparticles of hyperstar polymers encompassing drugs to selectively target triple negative breast cancer (TNBC) cell proliferation through STAT3 and topoisomerase-II pathways. This nano-cocktail was at least two to four fold better than the individual drugs and 6–20 times more selective than the parent drugs.

Graphical abstract: Combinatorial therapy for triple negative breast cancer using hyperstar polymer-based nanoparticles

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Publication details

The article was received on 15 Sep 2015, accepted on 21 Sep 2015 and first published on 22 Sep 2015


Article type: Communication
DOI: 10.1039/C5CC07709E
Citation: Chem. Commun., 2015,51, 16710-16713
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    Combinatorial therapy for triple negative breast cancer using hyperstar polymer-based nanoparticles

    S. K. Misra, X. Wang, I. Srivastava, M. K. Imgruet, R. W. Graff, A. Ohoka, T. L. Kampert, H. Gao and D. Pan, Chem. Commun., 2015, 51, 16710
    DOI: 10.1039/C5CC07709E

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