Jump to main content
Jump to site search

Issue 83, 2015
Previous Article Next Article

Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic

Author affiliations

Abstract

Herein we present a significant step towards next-generation antibody-based photodynamic therapeutics. Site-selective modification of a clinically relevant monoclonal antibody, with a serum-stable linker bearing a strained alkyne, allows for the controlled Cu-free “click” assembly of an in vitro active antibody-based PDT agent using a water soluble azide porpyhrin.

Graphical abstract: Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic

Back to tab navigation

Supplementary files

Publication details

The article was received on 19 Aug 2015, accepted on 24 Aug 2015 and first published on 24 Aug 2015


Article type: Communication
DOI: 10.1039/C5CC06985H
Citation: Chem. Commun., 2015,51, 15304-15307
  •   Request permissions

    Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic

    A. Maruani, H. Savoie, F. Bryden, S. Caddick, R. Boyle and V. Chudasama, Chem. Commun., 2015, 51, 15304
    DOI: 10.1039/C5CC06985H

Search articles by author

Spotlight

Advertisements