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Issue 81, 2015
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Copper-catalyzed oxidative decarboxylative C–H arylation of benzoxazoles with 2-nitrobenzoic acids

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Abstract

A copper-catalyzed oxidative decarboxylative coupling of benzoxazoles with 2-nitrobenzoic acids was developed. This methodology favors electron-rich benzoxazoles and electron-deficient benzoic acids and enables the preparation of a variety of arylated benzoxazoles in good yields. The trends in product yields suggest a delicate balance between the decarboxylation and C–H arylation steps.

Graphical abstract: Copper-catalyzed oxidative decarboxylative C–H arylation of benzoxazoles with 2-nitrobenzoic acids

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Publication details

The article was received on 07 Aug 2015, accepted on 21 Aug 2015 and first published on 21 Aug 2015


Article type: Communication
DOI: 10.1039/C5CC06645J
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2015,51, 15059-15062
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    Copper-catalyzed oxidative decarboxylative C–H arylation of benzoxazoles with 2-nitrobenzoic acids

    L. Chen, L. Ju, K. A. Bustin and J. M. Hoover, Chem. Commun., 2015, 51, 15059
    DOI: 10.1039/C5CC06645J

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