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Issue 85, 2015
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Dual functionality of phosphonic-acid-appended phthalocyanines: inhibitors of urokinase plasminogen activator and anticancer photodynamic agents

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Abstract

Phthalocyanines (Pcs) bearing phosphonic acid groups at the periphery exhibit a potential photodynamic effect to induce phototoxicity on human bladder cancer epithelial cells (UM-UC-3). In vitro photophysical and biological studies show high intrinsic ability to inhibit the activity of urokinase plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP-9).

Graphical abstract: Dual functionality of phosphonic-acid-appended phthalocyanines: inhibitors of urokinase plasminogen activator and anticancer photodynamic agents

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Publication details

The article was received on 05 Aug 2015, accepted on 26 Aug 2015 and first published on 26 Aug 2015


Article type: Communication
DOI: 10.1039/C5CC06561E
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Citation: Chem. Commun., 2015,51, 15550-15553
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    Dual functionality of phosphonic-acid-appended phthalocyanines: inhibitors of urokinase plasminogen activator and anticancer photodynamic agents

    N. Venkatramaiah, P. M. R. Pereira, F. A. Almeida Paz, C. A. F. Ribeiro, R. Fernandes and J. P. C. Tomé, Chem. Commun., 2015, 51, 15550
    DOI: 10.1039/C5CC06561E

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