Issue 74, 2015

Visible light mediated efficient oxidative benzylic sp3 C–H to ketone derivatives obtained under mild conditions using O2

Abstract

A photooxygenation of benzylic sp3 C–H reaction has been demonstrated using O2 mediated by visible light. This protocol provides a simple and mild route to obtain ketones from benzylic sp3 C–H bonds. Various benzylic sp3 C–H bonds can be transformed into the desired ketone derivatives in moderate to good yields. The 18O2 labelling experiments demonstrated that the oxygen introduced into ketone originated from dioxygen. A plausible mechanism has been proposed accordingly.

Graphical abstract: Visible light mediated efficient oxidative benzylic sp3 C–H to ketone derivatives obtained under mild conditions using O2

Supplementary files

Article information

Article type
Communication
Submitted
20 Jul 2015
Accepted
23 Jul 2015
First published
24 Jul 2015

Chem. Commun., 2015,51, 14046-14049

Author version available

Visible light mediated efficient oxidative benzylic sp3 C–H to ketone derivatives obtained under mild conditions using O2

H. Yi, C. Bian, X. Hu, L. Niu and A. Lei, Chem. Commun., 2015, 51, 14046 DOI: 10.1039/C5CC06015J

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