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Issue 77, 2015
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Biomimetic synthesis of Tramadol

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Abstract

Tramadol has recently been isolated from the roots and bark of Nauclea latifolia. A plausible biosynthetic pathway has been proposed and the product–precursor relationship has been probed by 13C position-specific isotope analysis. By further exploring this pathway, we demonstrate that a key step of the proposed pathway can be achieved using mild conditions that mimic in vivo catalysis.

Graphical abstract: Biomimetic synthesis of Tramadol

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Publication details

The article was received on 17 Jul 2015, accepted on 05 Aug 2015 and first published on 05 Aug 2015


Article type: Communication
DOI: 10.1039/C5CC05948H
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2015,51, 14451-14453
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    Biomimetic synthesis of Tramadol

    F. Lecerf-Schmidt, R. Haudecoeur, B. Peres, M. M. Ferreira Queiroz, L. Marcourt, S. Challal, E. Ferreira Queiroz, G. Sotoing Taiwe, T. Lomberget, M. Le Borgne, J. Wolfender, M. De Waard, R. J. Robins and A. Boumendjel, Chem. Commun., 2015, 51, 14451
    DOI: 10.1039/C5CC05948H

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