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Issue 83, 2015
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pKa tuning in quadrupolar-type two-photon ratiometric fluorescent membrane probes

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Abstract

Two bolaamphiphilic quadrupoles built from a fluorene core conjugated with azine endgroups were designed and successfully used to stain GUV membranes. Their quadrupolar character induces both a shift of the pKa values close to the physiological pH and large two-photon absorption responses (i.e. over 1000 GM for acidic forms). As such they hold promise as ratiometric two-photon pH probes for monitoring slight variations of pH near cell membranes using two-photon excitation in the NIR region.

Graphical abstract: pKa tuning in quadrupolar-type two-photon ratiometric fluorescent membrane probes

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Publication details

The article was received on 03 Jun 2015, accepted on 17 Jul 2015 and first published on 20 Jul 2015


Article type: Communication
DOI: 10.1039/C5CC04573H
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2015,51, 15245-15248
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    pKa tuning in quadrupolar-type two-photon ratiometric fluorescent membrane probes

    J. Daniel, C. Mastrodonato, A. Sourdon, G. Clermont, J. Vabre, B. Goudeau, H. Voldoire, S. Arbault, O. Mongin and M. Blanchard-Desce, Chem. Commun., 2015, 51, 15245
    DOI: 10.1039/C5CC04573H

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