The copper binding properties of metformin – QCM-D, XPS and nanobead agglomeration†
Abstract
Study of the copper binding properties of metformin is important for revealing its mechanism of action as a first-line type-2 diabetes drug. A quantitative investigation of interactions between metformin and L-cysteine–copper complexes was performed. The results suggest that metformin could interact with biological copper, which plays a key role in mitochondrial function.