5′- vs. 3′-end sugar conformational control in shaping up dinucleotides

Abstract

The 5′-end N-sugar puckering is currently believed to govern the intramolecular dinucleotide stacking. We demonstrate that if this 5′-conformation is indeed important in shaping up dinucleotide structures, the 3′-end sugar conformation can either potentiate or cancel the stacking capacity induced by the 5′-end N-sugar conformation.