Issue 61, 2015

Palladium-catalyzed asymmetric intermolecular Mizoroki–Heck reaction for construction of a chiral quaternary carbon center

Abstract

Palladium-catalyzed asymmetric intermolecular Mizoroki–Heck reaction for the construction of a chiral quaternary carbon center is developed, affording 2,2-disubstituted 2,5-dihydrofurans in high yield with excellent enantioselectivity. The products are easily converted into the corresponding butenolides with retention of enantioselectivity.

Graphical abstract: Palladium-catalyzed asymmetric intermolecular Mizoroki–Heck reaction for construction of a chiral quaternary carbon center

Supplementary files

Article information

Article type
Communication
Submitted
30 Apr 2015
Accepted
11 Jun 2015
First published
12 Jun 2015
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2015,51, 12235-12238

Author version available

Palladium-catalyzed asymmetric intermolecular Mizoroki–Heck reaction for construction of a chiral quaternary carbon center

Q. Zhang, S. Wan, D. Chen, C. Ding and X. Hou, Chem. Commun., 2015, 51, 12235 DOI: 10.1039/C5CC03601A

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