Multicomponent dipeptide hydrogels as extracellular matrix-mimetic scaffolds for cell culture applications

Wathsala Liyanage; Kanika Vats; Annada Rajbhandary; Danielle S. W. Benoit; Bradley L. Nilsson

doi:10.1039/C5CC03162A

Multicomponent dipeptide hydrogels as extracellular matrix-mimetic scaffolds for cell culture applications

Wathsala Liyanage,^a Kanika Vats,^b Annada Rajbhandary,^a Danielle S. W. Benoit^b^c^d and Bradley L. Nilsson*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Rochester, Rochester, USA
E-mail: nilsson@chem.rochester.edu

^b Department of Biomedical Engineering, University of Rochester, Rochester, USA

^c Department of Chemical Engineering, University of Rochester, Rochester, USA

^d The Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, USA

Abstract

Fmoc-3F-Phe-Arg-NH₂ and Fmoc-3F-Phe-Asp-OH dipeptides undergo coassembly to form two-component nanofibril hydrogels. These hydrogels support the viability and growth of NIH 3T3 fibroblast cells. The supramolecular display of Arg and Asp at the nanofibril surface effectively mimics the integrin-binding RGD peptide of fibronectin, without covalent connection between the Arg and Asp functionality.

Supplementary files

Publication details

The article was received on 16 Apr 2015, accepted on 10 Jun 2015 and first published on 10 Jun 2015

Article type: Communication

DOI: 10.1039/C5CC03162A

Author version available: Download Author version (PDF)

Citation: Chem. Commun., 2015,51, 11260-11263

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Multicomponent dipeptide hydrogels as extracellular matrix-mimetic scaffolds for cell culture applications

W. Liyanage, K. Vats, A. Rajbhandary, D. S. W. Benoit and B. L. Nilsson, Chem. Commun., 2015, 51, 11260
DOI: 10.1039/C5CC03162A
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Chemical Communications

Multicomponent dipeptide hydrogels as extracellular matrix-mimetic scaffolds for cell culture applications

Abstract

Supplementary files

Publication details

Multicomponent dipeptide hydrogels as extracellular matrix-mimetic scaffolds for cell culture applications

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