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Issue 58, 2015
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KOtBu-mediated annulation of acetonitrile with aldehyde: synthesis of substituted dihydropyridin-2(1H)-ones, pyridin-2(1H)-ones, and thiopyridin-2(1H)-ones

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Abstract

The KOtBu-mediated annulation of acetonitrile with aldehyde was observed, in which the cleavage of four C(sp3)–H bonds occurred and a total of eight new bonds were formed during the synthesis of substituted dihydropyridinones in the presence of peroxide. Furthermore, dihydropyridinones have been transformed into pyridinones using KOtBu in DMSO.

Graphical abstract: KOtBu-mediated annulation of acetonitrile with aldehyde: synthesis of substituted dihydropyridin-2(1H)-ones, pyridin-2(1H)-ones, and thiopyridin-2(1H)-ones

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Publication details

The article was received on 09 Apr 2015, accepted on 04 Jun 2015 and first published on 04 Jun 2015


Article type: Communication
DOI: 10.1039/C5CC02964C
Citation: Chem. Commun., 2015,51, 11658-11661
  • Open access: Creative Commons BY license
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    KOtBu-mediated annulation of acetonitrile with aldehyde: synthesis of substituted dihydropyridin-2(1H)-ones, pyridin-2(1H)-ones, and thiopyridin-2(1H)-ones

    A. Yadav, A. Verma, S. Patel, A. Kumar, V. Rathore, Meenakshi, S. Kumar and S. Kumar, Chem. Commun., 2015, 51, 11658
    DOI: 10.1039/C5CC02964C

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