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Issue 46, 2015
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Uncaging a catalytic hydrogen peroxide generator through the photo-induced release of nitric oxide from a {MnNO}6 complex

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Abstract

The photo-initiated cytotoxicity of a newly developed manganese nitrosyl {MnNO}6 complex (UG1NO) to HeLa cells is described. The complex was found to be strongly cytotoxic after being exposed to light with a wavelength of 650 nm. Cell death was caused by a manganese(II) complex, UG1, generated from UG1NO through the photo-dissociation of NO, rather than by NO directly. Mechanistic studies revealed that UG1 consumes O2 only in the presence of a reducing agent to catalytically produce H2O2.

Graphical abstract: Uncaging a catalytic hydrogen peroxide generator through the photo-induced release of nitric oxide from a {MnNO}6 complex

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Publication details

The article was received on 28 Mar 2015, accepted on 07 May 2015 and first published on 07 May 2015


Article type: Communication
DOI: 10.1039/C5CC02566D
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2015,51, 9539-9542
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    Uncaging a catalytic hydrogen peroxide generator through the photo-induced release of nitric oxide from a {MnNO}6 complex

    Y. Iwamoto, M. Kodera and Y. Hitomi, Chem. Commun., 2015, 51, 9539
    DOI: 10.1039/C5CC02566D

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