Issue 53, 2015
From the journal:

Chemical Communications

Selective inhibition of the hypoxia-inducible factor prolyl hydroxylase PHD3 by Zn(ii)†

Yu-Ran Na,ab   Dustin J. Woo,ac   Hyunah Choo,cd   Hak Suk Chung*ac  and  Eun Gyeong Yang*ac  

* Corresponding authors

a Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea
E-mail: eunyang@kist.re.kr, hschung@kist.re.kr
Fax: +82-2-958-5909
Tel: +82-2-958-5178

b Department of Chemistry, Research Institute for Natural Sciences, Korea University, Seoul 136-701, Republic of Korea

c Department of Biological Chemistry, KIST Campus, Korea University of Science and Technology (UST), Seoul 136-791, Republic of Korea

d Center for Neuromedicine, Brain Science Institute, Korea Institute of Science and Technology, Seoul 136-791, Republic of Korea

Abstract

We report herein that Zn(II) selectively inhibits the hypoxia-inducible factor prolyl hydroxylase PHD3 over PHD2, and does not compete with Fe(II). Independent of the oligomer formation induced by Zn(II), inhibition of the activity of PHD3 by Zn(II) involves Cys42 and Cys52 residues distantly located from the active site.

Graphical abstract: Selective inhibition of the hypoxia-inducible factor prolyl hydroxylase PHD3 by Zn(ii)

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Article information

DOI
https://doi.org/10.1039/C5CC02143J
Article type
Communication
Submitted
13 Mar 2015
Accepted
21 May 2015
First published
21 May 2015

Chem. Commun., 2015,51, 10730-10733

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Selective inhibition of the hypoxia-inducible factor prolyl hydroxylase PHD3 by Zn(II)

Y. Na, D. J. Woo, H. Choo, H. S. Chung and E. G. Yang, Chem. Commun., 2015, 51, 10730 DOI: 10.1039/C5CC02143J

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