Jump to main content
Jump to site search

Issue 57, 2015
Previous Article Next Article

A practical fluorogenic substrate for high-throughput screening of glutathione S-transferase inhibitors

Author affiliations

Abstract

We report a new fluorogenic substrate for glutathione S-transferase (GST), 3,4-DNADCF, enabling the assay with a low level of nonenzymatic background reaction. Inhibitors against Noppera-bo/GSTe14 from Drosophila melanogaster were identified by high throughput screening using 3,4-DNADCF, demonstrating the utility of this substrate.

Graphical abstract: A practical fluorogenic substrate for high-throughput screening of glutathione S-transferase inhibitors

Back to tab navigation

Supplementary files

Publication details

The article was received on 11 Mar 2015, accepted on 04 Jun 2015 and first published on 04 Jun 2015


Article type: Communication
DOI: 10.1039/C5CC02067K
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2015,51, 11459-11462
  •   Request permissions

    A practical fluorogenic substrate for high-throughput screening of glutathione S-transferase inhibitors

    Y. Fujikawa, F. Morisaki, A. Ogura, K. Morohashi, S. Enya, R. Niwa, S. Goto, H. Kojima, T. Okabe, T. Nagano and H. Inoue, Chem. Commun., 2015, 51, 11459
    DOI: 10.1039/C5CC02067K

Search articles by author

Spotlight

Advertisements