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Issue 37, 2015
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A fluorescent histone deacetylase (HDAC) inhibitor for cellular imaging

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Abstract

Fluorescence microscopy studies using 4-morpholinoscriptaid (4MS) demonstrated rapid cellular uptake of this scriptaid analogue into the cytoplasm but no nuclear penetration. As 4MS and scriptaid have the same in vitro activity against HDACs and KASUMI-1 cells; 4MS exemplifies a rational approach to subtly modify ‘profluorogenic’ substrates for intracellular studies.

Graphical abstract: A fluorescent histone deacetylase (HDAC) inhibitor for cellular imaging

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Publication details

The article was received on 11 Mar 2015, accepted on 02 Apr 2015 and first published on 02 Apr 2015


Article type: Communication
DOI: 10.1039/C5CC02059J
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Citation: Chem. Commun., 2015,51, 7827-7830
  • Open access: Creative Commons BY license
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    A fluorescent histone deacetylase (HDAC) inhibitor for cellular imaging

    C. L. Fleming, T. D. Ashton, C. Nowell, M. Devlin, A. Natoli, J. Schreuders and F. M. Pfeffer, Chem. Commun., 2015, 51, 7827
    DOI: 10.1039/C5CC02059J

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