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Issue 43, 2015
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Cucurbit[6]uril is an ultrasensitive 129Xe NMR contrast agent

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Abstract

A lack of molecular contrast agents has slowed the application of ultrasensitive hyperpolarized 129Xe NMR methods. Here, we report that commercially available cucurbit[6]uril (CB[6]) undergoes rapid xenon exchange kinetics at 300 K, and is detectable by Hyper-CEST NMR at 1.8 pM in PBS and at 1 μM in human plasma where many molecules, including polyamines, can compete with xenon for CB[6] binding.

Graphical abstract: Cucurbit[6]uril is an ultrasensitive 129Xe NMR contrast agent

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Publication details

The article was received on 03 Mar 2015, accepted on 21 Apr 2015 and first published on 21 Apr 2015


Article type: Communication
DOI: 10.1039/C5CC01826A
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2015,51, 8982-8985
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    Cucurbit[6]uril is an ultrasensitive 129Xe NMR contrast agent

    Y. Wang and I. J. Dmochowski, Chem. Commun., 2015, 51, 8982
    DOI: 10.1039/C5CC01826A

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