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Issue 49, 2015
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Synthesis of enantioenriched 1,2-trans-diamines using the borono-Mannich reaction with N-protected α-amino aldehydes

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Abstract

The three-component Petasis borono-Mannich reaction starting with easily accessible N-protected α-amino aldehydes produces efficiently and diastereoselectively 1,2-trans-diamines with an enantiomeric excess of up to 98%.

Graphical abstract: Synthesis of enantioenriched 1,2-trans-diamines using the borono-Mannich reaction with N-protected α-amino aldehydes

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Publication details

The article was received on 26 Feb 2015, accepted on 08 May 2015 and first published on 11 May 2015


Article type: Communication
DOI: 10.1039/C5CC01716E
Citation: Chem. Commun., 2015,51, 9991-9994
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    Synthesis of enantioenriched 1,2-trans-diamines using the borono-Mannich reaction with N-protected α-amino aldehydes

    S. Norsikian, M. Beretta, A. Cannillo, A. Martin, P. Retailleau and J. Beau, Chem. Commun., 2015, 51, 9991
    DOI: 10.1039/C5CC01716E

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