Issue 49, 2015

Synthesis of enantioenriched 1,2-trans-diamines using the borono-Mannich reaction with N-protected α-amino aldehydes

Abstract

The three-component Petasis borono-Mannich reaction starting with easily accessible N-protected α-amino aldehydes produces efficiently and diastereoselectively 1,2-trans-diamines with an enantiomeric excess of up to 98%.

Graphical abstract: Synthesis of enantioenriched 1,2-trans-diamines using the borono-Mannich reaction with N-protected α-amino aldehydes

Supplementary files

Article information

Article type
Communication
Submitted
26 Feb 2015
Accepted
08 May 2015
First published
11 May 2015

Chem. Commun., 2015,51, 9991-9994

Synthesis of enantioenriched 1,2-trans-diamines using the borono-Mannich reaction with N-protected α-amino aldehydes

S. Norsikian, M. Beretta, A. Cannillo, A. Martin, P. Retailleau and J. Beau, Chem. Commun., 2015, 51, 9991 DOI: 10.1039/C5CC01716E

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