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Issue 27, 2015
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A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

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Abstract

Azobenzene photoresponsive elements can be installed on sulfonylureas, yielding optical control over pancreatic beta cell function and insulin release. An obstacle to such photopharmacological approaches remains the use of ultraviolet-blue illumination. Herein, we synthesize and test a novel yellow light-activated sulfonylurea based on a heterocyclic azobenzene bearing a push–pull system.

Graphical abstract: A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

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Publication details

The article was received on 09 Feb 2015, accepted on 21 Feb 2015 and first published on 26 Feb 2015


Article type: Communication
DOI: 10.1039/C5CC01224D
Citation: Chem. Commun., 2015,51, 6018-6021
  • Open access: Creative Commons BY license
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    A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

    J. Broichhagen, J. A. Frank, N. R. Johnston, R. K. Mitchell, K. Šmid, P. Marchetti, M. Bugliani, G. A. Rutter, D. Trauner and D. J. Hodson, Chem. Commun., 2015, 51, 6018
    DOI: 10.1039/C5CC01224D

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