Issue 28, 2015
From the journal:

Chemical Communications

Stereoselective synthesis of a highly oxygenated decahydrocyclopenta[g]chromene derivative: the common tricyclic framework of leucosceptrine and leucosesterterpenone†

Hideki Abe,a   Yuri Horii,a   Megumi Hagiwara,a   Toyoharu Kobayashia  and  Hisanaka Ito*a  

* Corresponding authors

a School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
E-mail: itohisa@toyaku.ac.jp

Abstract

Stereoselective construction of the highly oxygenated decahydrocyclopenta[g]chromene skeleton, which is the tricyclic core of leucosceptrine, which possesses prolylendopeptidase inhibitory activity, and leucosesterterpenone, which exhibits anti-angiogenic activity, from Leucosceptrum canum, was achieved.

Graphical abstract: Stereoselective synthesis of a highly oxygenated decahydrocyclopenta[g]chromene derivative: the common tricyclic framework of leucosceptrine and leucosesterterpenone

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Article information

DOI
https://doi.org/10.1039/C5CC00879D
Article type
Communication
Submitted
30 Jan 2015
Accepted
25 Feb 2015
First published
27 Feb 2015

Chem. Commun., 2015,51, 6108-6110

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Stereoselective synthesis of a highly oxygenated decahydrocyclopenta[g]chromene derivative: the common tricyclic framework of leucosceptrine and leucosesterterpenone

H. Abe, Y. Horii, M. Hagiwara, T. Kobayashi and H. Ito, Chem. Commun., 2015, 51, 6108 DOI: 10.1039/C5CC00879D

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