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Issue 21, 2015
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Efficient direct 2,2,2-trifluoroethylation of indoles via C–H functionalization

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Abstract

A novel highly C3 selective metal free trifluoroethylation of indoles using 2,2,2-trifuoroethyl(mesityl)-iodonium triflate was developed. The methodology enables the introduction of a trifluoroethyl group in a fast and efficient reaction under mild conditions with high functional group tolerance. Beyond the synthetic developments, quantum chemical calculations provide a deeper understanding of the transformation.

Graphical abstract: Efficient direct 2,2,2-trifluoroethylation of indoles via C–H functionalization

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Publication details

The article was received on 19 Jan 2015, accepted on 05 Feb 2015 and first published on 06 Feb 2015


Article type: Communication
DOI: 10.1039/C5CC00519A
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Citation: Chem. Commun., 2015,51, 4488-4491
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    Efficient direct 2,2,2-trifluoroethylation of indoles via C–H functionalization

    G. L. Tolnai, A. Székely, Z. Makó, T. Gáti, J. Daru, T. Bihari, A. Stirling and Z. Novák, Chem. Commun., 2015, 51, 4488
    DOI: 10.1039/C5CC00519A

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