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Issue 28, 2015
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Development of an acid ceramidase activity-based probe

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Abstract

Acid ceramidase is responsible for the ultimate step in the catabolism of (glyco)sphingolipids by hydrolysis of ceramide into sphingosine and free fatty acid. Deficiency in acid ceramidase is the molecular basis of Farber disease. Here we report the synthesis and characterization of an activity-based acid ceramidase probe.

Graphical abstract: Development of an acid ceramidase activity-based probe

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Publication details

The article was received on 14 Jan 2015, accepted on 13 Feb 2015 and first published on 19 Feb 2015


Article type: Communication
DOI: 10.1039/C5CC00356C
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2015,51, 6161-6163
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    Development of an acid ceramidase activity-based probe

    C. M. J. Ouairy, M. J. Ferraz, R. G. Boot, M. P. Baggelaar, M. van der Stelt, M. Appelman, G. A. van der Marel, B. I. Florea, J. M. F. G. Aerts and H. S. Overkleeft, Chem. Commun., 2015, 51, 6161
    DOI: 10.1039/C5CC00356C

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