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Issue 45, 2015
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RGD-decorated conjugated polymer particles as fluorescent biomedical probes prepared by Sonogashira dispersion polymerization

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Abstract

Here, we present a facile one-step Sonogashira dispersion polymerization affording monodisperse conjugated polymer particles bearing accessible acetylene moieties on the surface. These acetylene groups are easily functionalized with biological recognition motifs using thiol–yne click chemistry. The resulting functional particles are applied as fluorescent probes for imaging of activated endothelial cells, which take up the particles via receptor mediated endocytosis.

Graphical abstract: RGD-decorated conjugated polymer particles as fluorescent biomedical probes prepared by Sonogashira dispersion polymerization

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Publication details

The article was received on 17 Dec 2014, accepted on 01 May 2015 and first published on 01 May 2015


Article type: Communication
DOI: 10.1039/C4CC10092A
Citation: Chem. Commun., 2015,51, 9358-9361
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    RGD-decorated conjugated polymer particles as fluorescent biomedical probes prepared by Sonogashira dispersion polymerization

    N. Anwar, A. Rix, W. Lederle and A. J. C. Kuehne, Chem. Commun., 2015, 51, 9358
    DOI: 10.1039/C4CC10092A

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