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Issue 12, 2015
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Label free detection of nucleic acids by modulating nanochannel surfaces

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Abstract

We develop surface-modified 100 nm silica nanofluidic channels that change in measured conductivity upon exposure to single- or double-stranded DNA. Through careful monitoring of both electromigrative and advective current in the channel, we can detect nanomolar concentrations of DNA. These results can be exploited for inexpensive, all-electronic DNA sensors.

Graphical abstract: Label free detection of nucleic acids by modulating nanochannel surfaces

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Publication details

The article was received on 01 Dec 2014, accepted on 15 Dec 2014 and first published on 16 Dec 2014


Article type: Communication
DOI: 10.1039/C4CC09599E
Citation: Chem. Commun., 2015,51, 2335-2338
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    Label free detection of nucleic acids by modulating nanochannel surfaces

    P. Crisalli, C. McCallum and S. Pennathur, Chem. Commun., 2015, 51, 2335
    DOI: 10.1039/C4CC09599E

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