Triphenylarsonium-functionalised gold nanoparticles: potential nanocarriers for intracellular therapeutics

Nikhil Lalwani; Yu-Su Chen; Gemma Brooke; Neil A. Cross; David W. Allen; Alan Reynolds; Jesús Ojeda; Graham J. Tizzard; Simon J. Coles; Neil Bricklebank

doi:10.1039/C4CC09304F

Triphenylarsonium-functionalised gold nanoparticles: potential nanocarriers for intracellular therapeutics†

Nikhil Lalwani,^a Yu-Su Chen,^a Gemma Brooke,^a Neil A. Cross,^a David W. Allen,^a Alan Reynolds,^b Jesús Ojeda,^b Graham J. Tizzard,^c Simon J. Coles

^c and Neil Bricklebank*^a

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* Corresponding authors

^a Biomedical Research Centre, Sheffield Hallam University, City Campus, Sheffield S1 1WB, UK
E-mail: n.bricklebank@shu.ac.uk

^b Experimental Techniques Centre, Brunel University, Kingston Lane, Uxbridge, Middlesex, UK

^c EPSRC National Crystallography Service, School of Chemistry, University of Southampton, Southampton, UK

Abstract

Two new triphenylarsonium alkylthiolate precursors, a thiosulfate zwitterion and a thioacetate salt, have been structurally characterised and their cytotoxicity evaluated against PC3 cells. The arsonium compounds have been used to prepare gold nanoparticles decorated with triphenylarsonium groups.

Chemical Communications

Triphenylarsonium-functionalised gold nanoparticles: potential nanocarriers for intracellular therapeutics†

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Triphenylarsonium-functionalised gold nanoparticles: potential nanocarriers for intracellular therapeutics

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