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Issue 19, 2015
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A metal-based tumour necrosis factor-alpha converting enzyme inhibitor

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Abstract

We report herein a novel iridium(III) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells.

Graphical abstract: A metal-based tumour necrosis factor-alpha converting enzyme inhibitor

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Publication details

The article was received on 21 Nov 2014, accepted on 09 Jan 2015 and first published on 09 Jan 2015


Article type: Communication
DOI: 10.1039/C4CC09251A
Citation: Chem. Commun., 2015,51, 3973-3976
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    A metal-based tumour necrosis factor-alpha converting enzyme inhibitor

    C. Leung, L. Liu, L. Lu, B. He, D. W. J. Kwong, C. Wong and D. Ma, Chem. Commun., 2015, 51, 3973
    DOI: 10.1039/C4CC09251A

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