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Issue 27, 2015
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Cascade catalysis – strategies and challenges en route to preparative synthetic biology

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Abstract

Nature's smartness and efficient assembling cascade type reactions inspired biologists and chemists all around the world. Tremendous effort has been directed towards the understanding and mimicking of such networks. In recent years considerable progress has been made in developing multistep one-pot reactions combining either advantage of chemo-, regio-, and stereoselectivity of biocatalysts or promiscuity and productivity of chemocatalysts. In this context several concepts, inspired by different disciplines (biocatalysis, metabolic engineering, synthetic chemistry, and material science), have been evolved. This review will focus on major contributions in the field of cascade reactions over the last three years.

Graphical abstract: Cascade catalysis – strategies and challenges en route to preparative synthetic biology

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Publication details

The article was received on 03 Nov 2014, accepted on 10 Dec 2014 and first published on 10 Dec 2014


Article type: Feature Article
DOI: 10.1039/C4CC08752F
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2015,51, 5798-5811
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    Cascade catalysis – strategies and challenges en route to preparative synthetic biology

    J. Muschiol, C. Peters, N. Oberleitner, M. D. Mihovilovic, U. T. Bornscheuer and F. Rudroff, Chem. Commun., 2015, 51, 5798
    DOI: 10.1039/C4CC08752F

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