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Issue 25, 2015
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Determination of receptor specificities for whole influenza viruses using multivalent glycan arrays

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Abstract

Influenza viruses bind to mucosal glycans to gain entry into a host organism and initiate infection. The target glycans are often displayed in multivalent arrangements on proteins; however, how glycan presentation influences viral specificity is poorly understood. Here, we report a microarray platform approximating native glycan display to facilitate such studies.

Graphical abstract: Determination of receptor specificities for whole influenza viruses using multivalent glycan arrays

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Publication details

The article was received on 31 Oct 2014, accepted on 31 Dec 2014 and first published on 31 Dec 2014


Article type: Communication
DOI: 10.1039/C4CC08613A
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2015,51, 5326-5329
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    Determination of receptor specificities for whole influenza viruses using multivalent glycan arrays

    M. L. Huang, M. Cohen, C. J. Fisher, R. T. Schooley, P. Gagneux and K. Godula, Chem. Commun., 2015, 51, 5326
    DOI: 10.1039/C4CC08613A

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