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Issue 5, 2015
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Ni-Catalyzed α-arylation of esters and amides with phenol derivatives

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Abstract

A nickel-catalyzed α-arylation of esters and amides with phenol derivatives has been accomplished. In the presence of our unique nickel catalyst, prepared in situ from Ni(cod)2, 3,4-bis(dicyclohexylphosphino)thiophene (dcypt), and K3PO4, various esters and amides undergo α-arylation with O-arylpivalates or O-arylcarbamates to afford the corresponding coupling products. The thus obtained α-aryl esters and amides are useful precursors of privileged motifs such as α-arylcarboxylic acids and β-arylamines.

Graphical abstract: Ni-Catalyzed α-arylation of esters and amides with phenol derivatives

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Publication details

The article was received on 25 Oct 2014, accepted on 20 Nov 2014 and first published on 21 Nov 2014


Article type: Communication
DOI: 10.1039/C4CC08426H
Citation: Chem. Commun., 2015,51, 855-857
  • Open access: Creative Commons BY-NC license
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    Ni-Catalyzed α-arylation of esters and amides with phenol derivatives

    E. Koch, R. Takise, A. Studer, J. Yamaguchi and K. Itami, Chem. Commun., 2015, 51, 855
    DOI: 10.1039/C4CC08426H

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