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Issue 8, 2015
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The formation of biodegradable micelles from a therapeutic initiator for enzyme-mediated drug delivery

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Abstract

The direct grafting of amphiphilic macromolecules by sequential n-carboxyanhydride ring-opening polymerisation (NCA ROP) from a therapeutic initiator enables the formation of monodisperse drug-containing micelles. The subsequent enzyme-mediated hydrolysis of the peptide component permits the programmed release of the encapsulated drug molecules, demonstrating a controlled drug delivery platform that negates any challenging payload loading procedures.

Graphical abstract: The formation of biodegradable micelles from a therapeutic initiator for enzyme-mediated drug delivery

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Publication details

The article was received on 23 Oct 2014, accepted on 02 Dec 2014 and first published on 02 Dec 2014


Article type: Communication
DOI: 10.1039/C4CC08387C
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2015,51, 1520-1523
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    The formation of biodegradable micelles from a therapeutic initiator for enzyme-mediated drug delivery

    M. Khuphe, A. Kazlauciunas, M. Huscroft and P. D. Thornton, Chem. Commun., 2015, 51, 1520
    DOI: 10.1039/C4CC08387C

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