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Issue 3, 2015
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Combining in-cell NMR and X-ray fluorescence microscopy to reveal the intracellular maturation states of human superoxide dismutase 1

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Abstract

An integrated approach which combines in-cell NMR spectroscopy with optical and X-ray fluorescence microscopy was developed to describe the intracellular maturation state of human Cu,Zn-SOD1. Microscopy data show a correlation between the intracellular levels of SOD1 and the content of zinc, corresponding to zinc binding to SOD1 observed by in-cell NMR.

Graphical abstract: Combining in-cell NMR and X-ray fluorescence microscopy to reveal the intracellular maturation states of human superoxide dismutase 1

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Publication details

The article was received on 14 Oct 2014, accepted on 13 Nov 2014 and first published on 13 Nov 2014


Article type: Communication
DOI: 10.1039/C4CC08129C
Citation: Chem. Commun., 2015,51, 584-587
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    Combining in-cell NMR and X-ray fluorescence microscopy to reveal the intracellular maturation states of human superoxide dismutase 1

    E. Luchinat, A. Gianoncelli, T. Mello, A. Galli and L. Banci, Chem. Commun., 2015, 51, 584
    DOI: 10.1039/C4CC08129C

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