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Issue 14, 2015
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Dendrimeric calcium-responsive MRI contrast agents with slow in vivo diffusion

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Abstract

We report a methodology which enables the preparation of dendrimeric contrast agents sensitive to Ca2+ when starting from the monomeric analogue. The Ca-triggered longitudinal relaxivity response of these agents is not compromised by undertaking synthetic transformations, despite structural changes. The in vivo MRI studies in the rat cerebral cortex indicate that diffusion properties of dendrimeric contrast agents have great advantages as compared to their monomeric equivalents.

Graphical abstract: Dendrimeric calcium-responsive MRI contrast agents with slow in vivo diffusion

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Publication details

The article was received on 24 Sep 2014, accepted on 30 Oct 2014 and first published on 31 Oct 2014


Article type: Communication
DOI: 10.1039/C4CC07540D
Citation: Chem. Commun., 2015,51, 2782-2785
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    Dendrimeric calcium-responsive MRI contrast agents with slow in vivo diffusion

    S. Gündüz, N. Nitta, S. Vibhute, S. Shibata, M. E. Mayer, N. K. Logothetis, I. Aoki and G. Angelovski, Chem. Commun., 2015, 51, 2782
    DOI: 10.1039/C4CC07540D

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