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Issue 6, 2015
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DNAzyme-based biosensors and nanodevices

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DNAzymes, screened through in vitro selection, have shown great promise as molecular tools in the design of biosensors and nanodevices. The catalytic activities of DNAzymes depend specifically on cofactors and show multiple enzymatic turnover properties, which make DNAzymes both versatile recognition elements and outstanding signal amplifiers. Combining nanomaterials with unique optical, magnetic and electronic properties, DNAzymes may yield novel fluorescent, colorimetric, surface-enhanced Raman scattering (SERS), electrochemical and chemiluminescent biosensors. Moreover, some DNAzymes have been utilized as functional components to perform arithmetic operations or as “walkers” to move along DNA tracks. DNAzymes can also function as promising therapeutics, when designed to complement target mRNAs or viral RNAs, and consequently lead to down-regulation of protein expression. This feature article focuses on the most significant achievements in using DNAzymes as recognition elements and signal amplifiers for biosensors, and highlights the applications of DNAzymes in logic gates, DNA walkers and nanotherapeutics.

Graphical abstract: DNAzyme-based biosensors and nanodevices

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The article was received on 31 Aug 2014, accepted on 13 Oct 2014 and first published on 14 Oct 2014

Article type: Feature Article
DOI: 10.1039/C4CC06855F
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Citation: Chem. Commun., 2015,51, 979-995
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    DNAzyme-based biosensors and nanodevices

    L. Gong, Z. Zhao, Y. Lv, S. Huan, T. Fu, X. Zhang, G. Shen and R. Yu, Chem. Commun., 2015, 51, 979
    DOI: 10.1039/C4CC06855F

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