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Issue 5, 2015
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Nanoparticles for inhibition of in vitro tumour angiogenesis: synergistic actions of ligand function and laser irradiation

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Abstract

Careful design of nanoparticles plays a crucial role in their biomedical applications. It not only defines the stability of nanoparticles in a biological medium but also programs their biological functionality and specific interactions with cells. Here, an inorganic nanoparticulate system engineered to have a dual role as anti-angiogenic and hyperthermic agent is presented. The inorganic rod-shaped core is designed to strongly absorb near-infrared laser irradiation through the surface plasmon resonance and convert it into localized heat, while a peptide coating acts as an anti-angiogenic drug, altogether inhibiting vascular growth. The synergistic dual action provides an improved inhibition of the in vitro tumour angiogenesis, offering new possibilities for the development of nano-engineered anti-angiogenic drugs for therapies.

Graphical abstract: Nanoparticles for inhibition of in vitro tumour angiogenesis: synergistic actions of ligand function and laser irradiation

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Publication details

The article was received on 18 Feb 2015, accepted on 13 Mar 2015 and first published on 23 Mar 2015


Article type: Paper
DOI: 10.1039/C5BM00053J
Citation: Biomater. Sci., 2015,3, 733-741
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    Nanoparticles for inhibition of in vitro tumour angiogenesis: synergistic actions of ligand function and laser irradiation

    D. Bartczak, O. L. Muskens, S. Nitti, T. M. Millar and A. G. Kanaras, Biomater. Sci., 2015, 3, 733
    DOI: 10.1039/C5BM00053J

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