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Issue 7, 2015
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Polymeric biomaterials for the delivery of platinum-based anticancer drugs

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Abstract

Since cisplatin, cis-diamminedichloroplatinum(II), received FDA approval for use in cancer treatment in 1978, platinum-based drugs have been one of the most widely used drugs for the treatment of tumors in testicles, ovaries, head and neck. However, there are concerns associated with the use of platinum-based anticancer drugs, owing to severe side effects and drug resistance. In order to overcome these limitations, various drug-delivery systems have been developed based on diverse organic and inorganic materials. In particular, the versatility of polymeric materials facilitates the tuning of drug-delivery systems to meet their primary goals. This review focuses on the progress made over the last five years in the application of polymeric nanoparticles for the delivery of platinum-based anticancer drugs. The present article not only describes the fundamental principles underlying the implementation of polymeric nanomaterials in platinum-based drug delivery, but also summarizes concepts and strategies employed in the development of drug-delivery systems.

Graphical abstract: Polymeric biomaterials for the delivery of platinum-based anticancer drugs

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Publication details

The article was received on 04 Feb 2015, accepted on 05 Apr 2015 and first published on 20 Apr 2015


Article type: Review Article
DOI: 10.1039/C5BM00039D
Citation: Biomater. Sci., 2015,3, 1002-1017
  • Open access: Creative Commons BY license
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    Polymeric biomaterials for the delivery of platinum-based anticancer drugs

    J. Kim, S. Pramanick, D. Lee, H. Park and W. J. Kim, Biomater. Sci., 2015, 3, 1002
    DOI: 10.1039/C5BM00039D

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