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Issue 7, 2015
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Redox-responsive self-assembled chain-shattering polymeric therapeutics

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Abstract

We report the design and development of redox-responsive chain-shattering polymeric therapeutics (CSPTs). CSPTs were synthesized by condensation polymerization and further modified with poly(ethylene glycol) (PEG) via “Click” reaction. Size-controlled CSPT nanoparticles (NPs) were formed through nanoprecipitation with high drug loading (up to 18%); the particle size increased in a concentration dependent manner. Drug release from particles was well controlled over 48 h upon redox triggering. The anticancer efficacy of the CSPT NPs was validated both in vitro and in vivo.

Graphical abstract: Redox-responsive self-assembled chain-shattering polymeric therapeutics

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Publication details

The article was received on 22 Dec 2014, accepted on 03 Feb 2015 and first published on 13 Feb 2015


Article type: Communication
DOI: 10.1039/C4BM00452C
Citation: Biomater. Sci., 2015,3, 1061-1065
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    Redox-responsive self-assembled chain-shattering polymeric therapeutics

    K. Cai, J. Yen, Q. Yin, Y. Liu, Z. Song, S. Lezmi, Y. Zhang, X. Yang, W. G. Helferich and J. Cheng, Biomater. Sci., 2015, 3, 1061
    DOI: 10.1039/C4BM00452C

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