Jump to main content
Jump to site search

Issue 7, 2015
Previous Article Next Article

Lipid-coated polymeric nanoparticles for cancer drug delivery

Author affiliations


Polymeric nanoparticles and liposomes have been the platform of choice for nanoparticle-based cancer drug delivery applications over the past decade, but extensive research has revealed their limitations as drug delivery carriers. A hybrid class of nanoparticles, aimed at combining the advantages of both polymeric nanoparticles and liposomes, has received attention in recent years. These core/shell type nanoparticles, frequently referred to as lipid–polymer hybrid nanoparticles (LPNs), possess several characteristics that make them highly suitable for drug delivery. This review introduces the formulation methods used to synthesize LPNs and discusses the strategies used to treat cancer, such as by targeting the tumor microenvironment or vasculature. Finally, it discusses the challenges that must be overcome to realize the full potential of LPNs in the clinic.

Graphical abstract: Lipid-coated polymeric nanoparticles for cancer drug delivery

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 09 Dec 2014, accepted on 26 Jan 2015 and first published on 11 Feb 2015

Article type: Review Article
DOI: 10.1039/C4BM00427B
Citation: Biomater. Sci., 2015,3, 923-936
  • Open access: Creative Commons BY-NC license
  •   Request permissions

    Lipid-coated polymeric nanoparticles for cancer drug delivery

    S. Krishnamurthy, R. Vaiyapuri, L. Zhang and J. M. Chan, Biomater. Sci., 2015, 3, 923
    DOI: 10.1039/C4BM00427B

Search articles by author