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Issue 7, 2015
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Lipid-coated polymeric nanoparticles for cancer drug delivery

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Abstract

Polymeric nanoparticles and liposomes have been the platform of choice for nanoparticle-based cancer drug delivery applications over the past decade, but extensive research has revealed their limitations as drug delivery carriers. A hybrid class of nanoparticles, aimed at combining the advantages of both polymeric nanoparticles and liposomes, has received attention in recent years. These core/shell type nanoparticles, frequently referred to as lipid–polymer hybrid nanoparticles (LPNs), possess several characteristics that make them highly suitable for drug delivery. This review introduces the formulation methods used to synthesize LPNs and discusses the strategies used to treat cancer, such as by targeting the tumor microenvironment or vasculature. Finally, it discusses the challenges that must be overcome to realize the full potential of LPNs in the clinic.

Graphical abstract: Lipid-coated polymeric nanoparticles for cancer drug delivery

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Publication details

The article was received on 09 Dec 2014, accepted on 26 Jan 2015 and first published on 11 Feb 2015


Article type: Review Article
DOI: 10.1039/C4BM00427B
Citation: Biomater. Sci., 2015,3, 923-936
  • Open access: Creative Commons BY-NC license
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    Lipid-coated polymeric nanoparticles for cancer drug delivery

    S. Krishnamurthy, R. Vaiyapuri, L. Zhang and J. M. Chan, Biomater. Sci., 2015, 3, 923
    DOI: 10.1039/C4BM00427B

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