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Issue 2, 2015
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MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin

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Abstract

Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in the fibres formed, which makes them valuable carriers for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.

Graphical abstract: MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin

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Publication details

The article was received on 12 Aug 2014, accepted on 09 Oct 2014 and first published on 28 Oct 2014


Article type: Communication
DOI: 10.1039/C4BM00297K
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Citation: Biomater. Sci., 2015,3, 246-249
  • Open access: Creative Commons BY license
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    MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin

    D. Kalafatovic, M. Nobis, N. Javid, P. W. J. M. Frederix, K. I. Anderson, B. R. Saunders and R. V. Ulijn, Biomater. Sci., 2015, 3, 246
    DOI: 10.1039/C4BM00297K

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