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Issue 16, 2015
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3,3′-Dioctadecyloxacarbocyanine perchlorate (DiO) as a fluorogenic probe for measurement of critical micelle concentration

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Abstract

Critical micelle concentration (CMC) is a key factor in applications of amphiphilic molecules, as it dictates the assembly state of the molecules. Nile Red (NR) is often used as a fluorogenic dye for the measurement of CMC values, but we have observed that NR is prone to aggregation, which leads to reduced reliability in CMC measurements. Here we evaluate 3,3′-dioctadecyloxacarbocyanine perchlorate (DiO) as an alternative fluorogenic dye for the measurement of CMC values. Both NR and DiO provide values comparable to those reported in the literature. However, we demonstrate that DiO provides improved consistency and is more user friendly than NR for measurement of CMC values.

Graphical abstract: 3,3′-Dioctadecyloxacarbocyanine perchlorate (DiO) as a fluorogenic probe for measurement of critical micelle concentration

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Publication details

The article was received on 04 Jun 2015, accepted on 17 Jul 2015 and first published on 22 Jul 2015


Article type: Paper
DOI: 10.1039/C5AY01444A
Author version available: Download Author version (PDF)
Citation: Anal. Methods, 2015,7, 6877-6882
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    3,3′-Dioctadecyloxacarbocyanine perchlorate (DiO) as a fluorogenic probe for measurement of critical micelle concentration

    A. M. Peterson, Z. Tan, E. M. Kimbrough and J. M. Heemstra, Anal. Methods, 2015, 7, 6877
    DOI: 10.1039/C5AY01444A

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