Issue 19, 2015
From the journal:

Analyst

Detection of thrombin based on aptamer isothermal exponential signal amplification technique†

Xiaotong Shen,a   Menghua Zhang,b   Shuyan Niu*a  and  Chao Shi*b  

* Corresponding authors

a Shandong Provincial Key Laboratory of Biochemical Analysis, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China
E-mail: chemsxt1990@163.com

b Key Laboratory of Sensor Analysis of Tumor Marker, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China

Abstract

In this report, a strategy based on an aptameric molecule switch to realize homogeneous and isothermal signal exponential amplification and protein detection has been described. This method was simple and sensitive, allowing detection of as low as 2.6 × 10−12 M thrombin.

Graphical abstract: Detection of thrombin based on aptamer isothermal exponential signal amplification technique

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Supplementary files

Article information

DOI
https://doi.org/10.1039/C5AN01313E
Article type
Communication
Submitted
30 Jun 2015
Accepted
19 Aug 2015
First published
19 Aug 2015

Analyst, 2015,140, 6489-6492

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Detection of thrombin based on aptamer isothermal exponential signal amplification technique

X. Shen, M. Zhang, S. Niu and C. Shi, Analyst, 2015, 140, 6489 DOI: 10.1039/C5AN01313E

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