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Issue 7, 2015
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Simultaneous intracellular redox potential and pH measurements in live cells using SERS nanosensors

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Abstract

Intracellular redox potential is a highly regulated cellular characteristic and is critically involved in maintaining cellular health and function. The dysregulation of redox potential can result in the initiation and progression of numerous diseases. Redox potential is determined by the balance of oxidants and reductants in the cell and also by pH. For this reason a technique for quantitative measurement of intracellular redox potential and pH is highly desirable. In this paper we demonstrate how surface enhanced Raman scattering (SERS) nanosensors can be used for multiplexed measurement of both pH and redox potential in live single cells.

Graphical abstract: Simultaneous intracellular redox potential and pH measurements in live cells using SERS nanosensors

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Publication details

The article was received on 23 Dec 2014, accepted on 11 Feb 2015 and first published on 20 Feb 2015


Article type: Paper
DOI: 10.1039/C4AN02365J
Citation: Analyst, 2015,140, 2330-2335
  • Open access: Creative Commons BY license
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    Simultaneous intracellular redox potential and pH measurements in live cells using SERS nanosensors

    L. E. Jamieson, A. Jaworska, J. Jiang, M. Baranska, D. J. Harrison and C. J. Campbell, Analyst, 2015, 140, 2330
    DOI: 10.1039/C4AN02365J

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