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Issue 1, 2015
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Glyconanoparticles for colorimetric bioassays

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Abstract

Carbohydrate molecules are involved in many of the cellular processes that are important for life. By combining the specific analyte targeting of carbohydrates with the multivalent structure and change of solution colour as a consequence of plasmonic interactions with the aggregation of metal nanoparticles, glyconanoparticles have been used extensively for the development of bioanalytical assays. The noble metals used to create the nanocore, the methodologies used to assemble the carbohydrates on the nanoparticle surface, the carbohydrate chosen for each specific target, the length of the tether that separates the carbohydrate from the nanocore and the density of carbohydrates on the surface all impact on the structural formation of metal based glyconanoparticles. This tutorial review highlights these key components, which directly impact on the selectivity and sensitivity of the developed bioassay, for the colorimetric detection of lectins, toxins and viruses.

Graphical abstract: Glyconanoparticles for colorimetric bioassays

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Publication details

The article was received on 09 Aug 2014, accepted on 23 Sep 2014 and first published on 03 Oct 2014


Article type: Tutorial Review
DOI: 10.1039/C4AN01466A
Citation: Analyst, 2015,140, 59-70
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    Glyconanoparticles for colorimetric bioassays

    M. J. Marín, C. L. Schofield, R. A. Field and D. A. Russell, Analyst, 2015, 140, 59
    DOI: 10.1039/C4AN01466A

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