Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 2, 2014
Previous Article Next Article

Remarkable anticancer activity of ferrocenyl-terpyridine platinum(II) complexes in visible light with low dark toxicity

Author affiliations


Ferrocenyl platinum(II) complexes (1–3), viz. [Pt(Fc-tpy)Cl]Cl (1), [Pt(Fc-tpy)(NPC)]Cl (2, HNPC = N-propargyl carbazole) and [Pt(Fc-bpa)Cl]Cl (3), were prepared, characterized and their anti-proliferative properties in visible light in human keratinocyte (HaCaT) cell lines have been studied. [Pt(Ph-tpy)Cl]Cl (4) was prepared and used as a control. Complexes 1 and 3, structurally characterized by X-ray crystallography, show distorted square-planar geometry for the platinum(II) centre. Complexes 1 and 2 having the Fc-tpy ligand showed an intense absorption band at ∼590 nm. The ferrocenyl complexes are redox active showing the Fc+–Fc couple near 0.6 V vs. SCE in DMF–0.1 M tetrabutylammonium perchlorate (TBAP). Complexes 1–3 showed external binding to calf thymus DNA. Both 1 and 2 showed remarkable photocytotoxicity in HaCaT cell lines giving respective IC50 values of 9.8 and 12.0 μM in visible light of 400–700 nm with low dark toxicity (IC50 >60 μM). Fluorescent imaging studies showed the spread of the complexes throughout the cell localising both in cytoplasm and the nucleus. The ferrocenyl complexes triggered apoptosis on light exposure as evidenced from the Annexin V-FITC/PI and DNA ladder formation assays. Spectral studies revealed the formation of ferrocenium ions upon photo-irradiation generating cytotoxic hydroxyl radicals via a Fenton type mechanism. The results are rationalized from a TDDFT study that shows involvement of ferrocene and the platinum coordinated terpyridine moiety as respective HOMO and LUMO.

Graphical abstract: Remarkable anticancer activity of ferrocenyl-terpyridine platinum(ii) complexes in visible light with low dark toxicity

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 16 Jul 2013, accepted on 01 Oct 2013 and first published on 02 Oct 2013

Article type: Paper
DOI: 10.1039/C3DT51922H
Citation: Dalton Trans., 2014,43, 751-763
  •   Request permissions

    Remarkable anticancer activity of ferrocenyl-terpyridine platinum(II) complexes in visible light with low dark toxicity

    K. Mitra, U. Basu, I. Khan, B. Maity, P. Kondaiah and A. R. Chakravarty, Dalton Trans., 2014, 43, 751
    DOI: 10.1039/C3DT51922H

Search articles by author