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Issue 9, 2014
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NIR initiated and pH sensitive single-wall carbon nanotubes for doxorubicin intracellular delivery

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Abstract

In this work, we synthesized a pH sensitive poly(ethylene glycol)–doxorubicin (PEG–DOX) on single-wall carbon nanotubes (SWNTs). Using multimodal nonlinear optical imaging microscopy, we found that low power (1 mW cm−2) near-infrared radiation can initiate prodrug burst release from the carbon nanotubes in seconds. The successful SWNTs capping with PEG–DOX (denoted PEG–DOX@SWNT) was determined by transmission electron microscopy and FTIR results. The in vitro release of DOX from the PEG–DOX@SWNT was evaluated upon changes of pH values and NIR treating time. The cytotoxicity of the PEG–DOX@SWNT was also evaluated. This dual-sensitive delivery system based on SWNTs provides a facile approach to promote drug release and kill cancer cells.

Graphical abstract: NIR initiated and pH sensitive single-wall carbon nanotubes for doxorubicin intracellular delivery

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Publication details

The article was received on 01 Oct 2013, accepted on 25 Nov 2013 and first published on 26 Nov 2013


Article type: Paper
DOI: 10.1039/C3TB21362E
Citation: J. Mater. Chem. B, 2014,2, 1125-1135
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    NIR initiated and pH sensitive single-wall carbon nanotubes for doxorubicin intracellular delivery

    S. Liu, A. C.-T. Ko, W. Li, W. Zhong and M. Xing, J. Mater. Chem. B, 2014, 2, 1125
    DOI: 10.1039/C3TB21362E

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