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Issue 10, 2014
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Conferring an adhesion layer with mineralization-inducing capabilities for preparing organic–inorganic hybrid microcapsules

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Abstract

In this study, a novel approach to prepare organic–inorganic hybrid microcapsules was developed by conferring an adhesion layer with mineralization-inducing capabilities under mild conditions. The wall of hybrid microcapsules consisted of two layers: an organic layer (adhesion layer) and an inorganic layer (biomineral layer). The organic layer was formed through rapid oxidative self-polymerization of dopamine into polydopamine (PDA) on a CaCO3 (PSS-doped) template surface. Then cysteamine was grafted onto the adhesion layer to induce the formation of titania, thus, constructing the biomineral layer. Notably, cysteamine acted as a bridge between the two layers to enhance the interfacial stability: (1) the –SH groups of cysteamine can react with the catechol groups of PDA to form covalent bonds through Michael addition or Schiff base reaction; (2) the –NH2 groups of cysteamine can induce the formation of titania. The hybrid microcapsules (PDA/cysteamine/Ti microcapsules) acquired much higher mechanical stability than pure PDA microcapsules. At 20% (w/v) PSS solution, 65% of PDA microcapsules were deformed, whereas, at 40% (w/v) PSS solution, only ∼6% of PDA/cysteamine/Ti microcapsules were deformed. Finally, catalase (CAT) was physically encapsulated in the microcapsule lumen. The immobilized CAT exhibited good recycling stability and high storage stability. Besides biocatalysis, the hybrid microcapsules may find applications in biomedical and biosensing fields.

Graphical abstract: Conferring an adhesion layer with mineralization-inducing capabilities for preparing organic–inorganic hybrid microcapsules

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Publication details

The article was received on 29 Aug 2013, accepted on 29 Nov 2013 and first published on 06 Dec 2013


Article type: Paper
DOI: 10.1039/C3TB21202E
Citation: J. Mater. Chem. B, 2014,2, 1371-1378
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    Conferring an adhesion layer with mineralization-inducing capabilities for preparing organic–inorganic hybrid microcapsules

    W. Zhang, J. Shi, X. Wang, Z. Jiang, X. Song and Q. Ai, J. Mater. Chem. B, 2014, 2, 1371
    DOI: 10.1039/C3TB21202E

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